Telehealth has made medically supervised GLP-1 weight-loss programs far easier to access — you complete an online assessment, a licensed provider reviews it, and if appropriate, medication ships to your door. Below we compare three of the more accessible platforms offering compounded semaglutide and tirzepatide: Trimi, Telos RX, and Ageless. All three connect you with U.S.-licensed providers and fill through licensed pharmacies; they differ on price, formats, and how much else they offer.
The short version: Trimi has the lowest entry price (semaglutide from about $99/month). Telos RX stands out for tirzepatide, including a needle-free oral option. Ageless is the all-in-one pick — its GLP-1 plans include B12, and it's the only one here that also covers hormones and longevity. The right choice depends on which medication and format a licensed provider decides is appropriate for you.
At a glance
| Trimi | Telos RX | Ageless | |
|---|---|---|---|
| Best for | Lowest-cost entry | Tirzepatide & needle-free oral | All-in-one (weight, hormones, longevity) |
| GLP-1 options | Compounded semaglutide, tirzepatide | Compounded tirzepatide (injectable & oral), semaglutide | Compounded semaglutide, tirzepatide (+ B12); sublingual drops |
| Starting price | From $99/mo | From $129/mo | From $199/mo |
| Formats | Injection | Injection or needle-free oral | Injection or sublingual drops |
| Also offers | — | NAD+, sermorelin, more | TRT, NAD+, sermorelin |
| Pharmacy | Licensed 503A | Licensed 503A | USA-based licensed pharmacy |
| Shipping | Free overnight | Free 48-hour | Ships with supplies |
| Trust signal | LegitScript-certified | Board-certified team | US-licensed clinicians |
Prices reflect the lowest published monthly rate and are set by each platform; they can change. Confirm current pricing on each platform's site.
What is a compounded GLP-1 program?
GLP-1 medications like semaglutide and tirzepatide are prescription treatments used in medically supervised weight management. Through a telehealth platform, a licensed provider reviews your health history and, if appropriate, can prescribe a compounded version — a formulation prepared by a licensed compounding pharmacy rather than a mass-manufactured branded product.
The key distinction: compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness, or quality before they're dispensed. Branded GLP-1 medications go through FDA approval; compounded versions do not. Whether a compounded option is right for you is a decision only a licensed provider can make, and not everyone will qualify.
Trimi — best value
Trimi
What stands out: Trimi is built around a low, transparent entry price — compounded semaglutide starts around $99/month, among the lower starting points available, and pricing is flat as your dose is adjusted. It's physician-led with a 50-state licensed provider network, medications are prepared by licensed 503A pharmacies, and the platform is LegitScript-certified. Shipping is free and overnight, support is 24/7, and it's FSA/HSA eligible.
Best for: the most affordable entry into a medically supervised GLP-1 program, and anyone who prefers a straightforward injectable plan with flat pricing.
Telos RX — best for tirzepatide & needle-free
Telos RX
What stands out: Telos RX leans into tirzepatide and format flexibility. Alongside the standard weekly injection, it offers a needle-free oral tirzepatide — a daily under-the-tongue option formulated with ondansetron (an anti-nausea medication). Medications are prepared by licensed 503A pharmacies with a board-certified medical team, pricing is flat across doses, shipping is free within 48 hours, and there's 24/7 provider messaging. It's FSA/HSA eligible and adds pay-over-time options (Affirm, Afterpay, Klarna).
Best for: people focused on tirzepatide, anyone who'd rather avoid needles, and those who want financing flexibility.
Ageless — best all-in-one
Ageless
What stands out: Ageless offers compounded semaglutide and tirzepatide with B12 included for energy support, plus a needle-free sublingual tirzepatide for people who prefer drops over injections. Its real differentiator is breadth: it's the only platform here that also covers TRT, NAD+, and sermorelin, so weight, hormones, and longevity can live under one account with U.S.-licensed clinicians and a USA-based pharmacy.
Best for: anyone who wants one platform for multiple goals (weight plus hormones and longevity), values B12 bundled into a GLP-1 plan, or prefers a sublingual option.
Head to head
Price
On entry price, Trimi leads — semaglutide from about $99/month, versus Telos RX from $129/month (oral tirzepatide) and Ageless from $199/month. Ageless is the priciest to start, but its GLP-1 plans bundle B12 and it covers more verticals; Trimi is the pick if the lowest number is the priority. All three use flat pricing that doesn't climb as your dose is adjusted.
Formats
Trimi offers a weekly injection. Telos RX adds a needle-free oral tirzepatide (with built-in anti-nausea). Ageless offers injections plus needle-free sublingual drops. If avoiding needles matters, Telos RX and Ageless both have options; Trimi is injection-only.
Breadth
This is where Ageless separates itself. Trimi and Telos RX are focused primarily on weight (Telos also offers some longevity options), while Ageless spans GLP-1 weight loss, TRT, NAD+, and sermorelin. If you expect to pursue more than one goal, consolidating with one provider can be simpler.
Licensing & safety signals
All three connect you with U.S.-licensed providers and fill through licensed pharmacies. Trimi additionally holds LegitScript certification, a third-party standard some people look for. As always, the decision that matters most — whether a given medication is right for you — is made by your provider, not the platform.
How to choose
- Choose Trimi if the lowest entry price is the priority and you're comfortable with a weekly injection.
- Choose Telos RX if you specifically want tirzepatide or a needle-free oral option, or want pay-over-time financing.
- Choose Ageless if you want one platform for weight, hormones, and longevity, prefer B12 bundled in, or want a sublingual option.
- Either way, a licensed provider decides the medication and dose after reviewing your health history — so the practical first step is completing an assessment and seeing what you qualify for.
Want a closer look at the two most affordable options side by side? Read our detailed Trimi vs Telos RX comparison.
How we compare
Longevity Compass only lists platforms that connect patients with licensed providers and fill through licensed pharmacies. We compare on price transparency, treatment and format options, breadth, shipping, support, and third-party trust signals — not on which platform pays us the most. Read our full Editorial Policy and Advertising Disclosure for details.
Frequently asked questions
Are compounded GLP-1 medications FDA-approved?
No. Compounded medications are prepared by compounding pharmacies and are not FDA-approved; the FDA does not evaluate them for safety, effectiveness, or quality before use. Branded GLP-1 medications are FDA-approved; compounded versions are not.
Which compounded GLP-1 program is cheapest?
Of these three, Trimi has the lowest published starting price — compounded semaglutide from around $99/month — versus Telos RX from $129/month and Ageless from $199/month. Prices are set by each platform and can change.
Which programs offer a needle-free option?
Telos RX offers a needle-free daily oral tirzepatide, and Ageless offers needle-free sublingual tirzepatide drops. Trimi's GLP-1 options are weekly injections.
Do I need a prescription?
Yes. All three require an online health assessment reviewed by a licensed provider, who decides whether a prescription is appropriate. Not everyone will qualify.
Which platform also covers hormones and longevity?
Ageless is the only one of the three that also offers TRT, NAD+, and sermorelin alongside its GLP-1 weight-loss programs. Telos RX offers some longevity options as well.