If you're weighing telehealth options for a compounded GLP-1 program, Trimi and Telos RX are two of the more accessible platforms available today. Both connect you with U.S.-licensed providers and fill prescriptions through licensed compounding pharmacies — but they differ on price, the formats they offer, and the extras around them.
The short version: Trimi tends to have the lower entry price, with compounded semaglutide starting around $99/month. Telos RX stands out for tirzepatide options — including a needle-free oral version — plus pay-over-time financing. Neither is "better" universally; the right fit depends on which medication and format a licensed provider decides is appropriate for you.
At a glance
| Trimi | Telos RX | |
|---|---|---|
| Best for | Lowest-cost entry point | Tirzepatide options & needle-free oral |
| Medications | Compounded semaglutide & tirzepatide | Compounded tirzepatide (injectable & oral), semaglutide |
| Starting price | From $99/mo (semaglutide); tirzepatide from $125/mo | From $129/mo (oral tirzepatide); injectable tirzepatide from $139/mo |
| Formats | Weekly injection | Weekly injection or daily needle-free oral |
| Pharmacy | Licensed 503A compounding pharmacy | Licensed 503A compounding pharmacy |
| Shipping | Free overnight | Free 48-hour |
| Support | 24/7 care-team messaging | 24/7 provider messaging |
| Payment | FSA/HSA eligible | FSA/HSA eligible; pay-over-time (Affirm, Afterpay, Klarna) |
| Trust signals | LegitScript-certified; 50-state provider network | Board-certified medical team; U.S.-licensed providers |
Prices and details are set by each platform and can change; confirm current pricing on the platform's own site.
What is a compounded GLP-1 program?
GLP-1 medications like semaglutide and tirzepatide are prescription treatments used in medically supervised weight management. Through telehealth platforms, a licensed provider reviews your health history and, if appropriate, can prescribe a compounded version — a formulation prepared by a licensed compounding pharmacy rather than a mass-manufactured branded product.
This is an important distinction: compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness, or quality before they're dispensed. Branded GLP-1 medications go through FDA approval; compounded versions do not. Whether a compounded option is appropriate for you is a decision only a licensed provider can make, and not everyone will qualify.
Both platforms below operate on the same basic model: a quick online health assessment, provider review, and — if prescribed — home delivery, with ongoing messaging for adjustments and refills.
Trimi
Trimi
What stands out: Trimi is built around a low, transparent entry price. Compounded semaglutide starts around $99/month, which is among the lower starting points you'll find, and pricing is flat as your dose is adjusted, so it doesn't climb as you titrate. It's physician-led with a 50-state licensed provider network, medications are prepared by licensed 503A pharmacies, and the platform is LegitScript-certified. Shipping is free and overnight, support is 24/7, and it's FSA/HSA eligible.
Who it's for: people who want the most affordable entry into a medically supervised GLP-1 program, prefer a straightforward injectable plan, and value flat pricing.
Telos RX
Telos RX
What stands out: Telos RX leans into tirzepatide and format flexibility. Alongside the standard weekly injection, it offers a needle-free oral tirzepatide — a daily under-the-tongue option formulated with ondansetron (an anti-nausea medication) — which is genuinely differentiated for people who'd rather skip needles. Medications are prepared by licensed 503A pharmacies with a board-certified medical team, pricing is flat across doses, shipping is free within 48 hours, and there's 24/7 provider messaging. It's FSA/HSA eligible and adds pay-over-time options (Affirm, Afterpay, Klarna).
Who it's for: people focused on tirzepatide specifically, anyone who prefers a needle-free option, and those who want financing flexibility.
Head to head
Price
Trimi has the lower published entry point — semaglutide from about $99/month versus Telos RX's tirzepatide from about $129/month (oral) or $139/month (injectable). If your provider steers you toward semaglutide and budget is the priority, Trimi's starting price is hard to beat. Both use flat pricing that doesn't increase as your dose is adjusted.
Formats
This is the clearest difference. Trimi offers a weekly injection. Telos RX offers both a weekly injection and a needle-free daily oral tirzepatide with built-in anti-nausea. If avoiding needles matters to you, Telos RX is the only one of the two with that option.
Shipping & support
Both include free shipping and 24/7 messaging. Trimi advertises free overnight shipping; Telos RX advertises free 48-hour shipping. Practically, both get medication to your door quickly after a prescription is issued.
Licensing & safety signals
Both connect you with U.S.-licensed providers and fill through licensed 503A compounding pharmacies. Trimi additionally holds LegitScript certification, a third-party standard some people look for when vetting telehealth platforms. As always, the meaningful safety decision — whether a given medication is right for you — is made by your provider, not the platform.
How to choose
- Choose Trimi if the lowest entry price is your priority, you're comfortable with a weekly injection, and you'd value a LegitScript-certified platform.
- Choose Telos RX if you specifically want tirzepatide, prefer a needle-free oral option, or want pay-over-time financing.
- Either way, the medication and dose are decided by a licensed provider after reviewing your health history — so the practical first step is completing an assessment and seeing what you qualify for.
How we compare
Longevity Compass only lists platforms that connect patients with licensed providers and fill through licensed pharmacies. We compare on price transparency, treatment and format options, shipping, support, and third-party trust signals — not on which platform pays us the most. Read our full Editorial Policy and Advertising Disclosure for details.
Frequently asked questions
Are compounded GLP-1 medications FDA-approved?
No. Compounded medications are prepared by compounding pharmacies and are not FDA-approved; the FDA does not evaluate them for safety, effectiveness, or quality before use. Branded GLP-1 medications are FDA-approved; compounded versions are not.
Is Trimi or Telos RX cheaper?
Trimi has the lower published starting price — compounded semaglutide from around $99/month, versus Telos RX tirzepatide from around $129/month (oral). Prices are set by each platform and can change, so confirm current pricing on their sites.
Do I need a prescription?
Yes. Both platforms require an online health assessment reviewed by a licensed provider, who decides whether a prescription is appropriate. Not everyone will qualify.
Is there a needle-free option?
Telos RX offers a needle-free daily oral tirzepatide (formulated with an anti-nausea medication). Trimi's GLP-1 options are weekly injections.
Are these platforms legitimate?
Both connect patients with U.S.-licensed providers and use licensed 503A compounding pharmacies, and Trimi holds LegitScript certification. This article is informational and not medical advice — any treatment decision is made between you and a licensed provider.